Enhanced Wet Milling Technology for API Size Reduction
API size reduction achieved a mean volume (mV) particle size of between 12 17 µm for compounds with typical starting PSD''s of between 84 179 µm. Increased tip speed achieved an additional 30 60% reduction of mV d95 for a wide range of APIs – whether the starting crystals were needle, plate or blockshaped (see figures 1 through 3).